Moderna Inc. said Monday its experimental vaccine was 94.5% effective in preventing COVID-19 based on interim data from a late-stage clinical trial, becoming the second U.S. company in a week to report results that far exceed expectations.
Together with Pfizer Inc's vaccine, also shown to be more than 90% effective, and pending more safety data and regulatory review, the United States could have two vaccines authorized for emergency use in December with as many as 60 million doses of vaccine available by the year's end.
Next year, the U.S. government could have access to more than 1 billion doses just from the two vaccine makers, more than needed for the country's 330 million residents.
The vaccines, both built using new technology known as messenger RNA or mRNA, represent powerful new tools to fight a pandemic that has infected 54 million people worldwide and killed 1.3 million. The news also comes at time when COVID-19 cases are soaring, hitting new records in the United States and pushing some European countries back into lockdowns.
"We are going to have a vaccine that can stop COVID-19," Moderna President Stephen Hoge said in a telephone interview.
Moderna's interim analysis was based on 95 infections among trial participants who received either a placebo or the vaccine. Of those, only five infections occurred in those who received the vaccine, which is administered in two shots 28 days apart.
A key advantage of Moderna's vaccine is that it does not need ultra-cold storage like Pfizer's, making it easier to distribute. Moderna expects it to be stable at standard refrigerator temperatures of 2 to 8 degrees Celsius (36 to 48°F) for 30 days and it can be stored for up to 6 months at -20 degrees Celsius.
Pfizer’s vaccine must be shipped and stored at minus 70 degrees Celsius, the sort of temperature typical of an Antarctic winter. At standard refrigerator temperatures, it can be stored for up to five days.
The data from Moderna's 30,000 participant-strong trial also showed the vaccine prevented cases of severe COVID-19, a question that still remains with the Pfizer vaccine. Of the 95 cases in Moderna's trial, 11 were severe and all 11 occurred among volunteers who got the placebo.
Moderna, part of the U.S. government's Operation Warp Speed program, expects to produce around 20 million doses of the vaccine for the United States this year, millions of which the company has already made, and is ready to ship if it receives FDA authorization.
"Assuming we get an emergency use authorization, we'll be ready to ship through Warp Speed almost in hours," Hoge said. "So it could start being distributed instantly."
The 95 cases of COVID-19 included several key groups who are at increased risk for severe disease, including 15 cases in adults aged 65 and older and 20 in participants from racially diverse groups.
Most side effects were mild to moderate. A significant proportion of volunteers, however, experienced more severe aches and pains after taking the second dose, including about 10% who had fatigue severe enough to interfere with daily activities while another 9% had severe body aches. Most of these complaints were generally short-lived, the company said.
Moderna's data provide further validation of the promising but previously unproven mRNA platform, which turns the human body into a vaccine factory by coaxing cells to make certain virus proteins that the immune system sees as a threat and mounts a response against.
Moderna expects to have enough safety data required for U.S. authorization in the next week or so and the company expects to file for emergency use authorization in the coming weeks.
The United States has the world's highest known number of COVID-19 cases and deaths with more than 11 million infections and nearly 250,000 deaths.
The Trump Administration has primarily relied on development of vaccines and treatments as its response to the pandemic. Moderna has received nearly $1 billion in research and development funding from the U.S. government and has a $1.5 billion deal for 100 million doses. The U.S. government also has an option for another 400 million doses.
The company hopes to have between 500 million and 1 billion doses in 2021, split between its U.S. and international manufacturing sites and dependent in part on demand.
The U.S. government has said COVID-19 vaccines will be provided free to Americans, whether they have health insurance, are uninsured or are covered by government health programs such as Medicare.
Moderna also said it will use its data to seek authorization in Europe and other regions.
Other countries such as China and Russia have already begun vaccinations. Russia licensed its “Sputnik-V” COVID-19 vaccine for domestic use in August before it released data from large-scale trials. It said on Nov. 11 that its vaccine was 92% effective based on 20 infections in its large trial.
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Like our page on facebook @ Info4everybody Last Wednesday, we published the success story from Dr. Vladimir Zelenko, a board-certified family practitioner in New York, after he successfully treated 350 coronavirus patients with 100 percent success using a cocktail of drugs: hydroxychloroquine, in combination with azithromycin (Z-Pak), an antibiotic to treat secondary infections, and zinc sulfate. Dr. Zelenko said he saw the symptom of shortness of breath resolved within four to six hours after treatment. Do you know that the ancient Egypt were civilized by architects from the (500,000 - 4000 BC) Nsukka Civiliation? Now, Dr. Zelenko provides updates on the treatment after he successfully treated 699 COVID-19 patients in New York. In an exclusive interview with former New York Mayor, Rudy Giuliani, Dr. Vladmir Zelenko shares the results of his latest study, which showed that out of his 699 patients treated, zero patients died, zero patients intubated, and four ho
THE AKAN Copied from the book, Reality as Myth by Onyeji Nnaji . The influence of the Akan on their content nations lies on their population and commonwealth of their brother nations. The Akan are one of the largest ethnic groups in West Africa. Their population is scattered across West Africa and beyond. Among this huge population of the Akan, the Ghanaians are more popular, perhaps because of the political influence of the Ashanti Empire in the area. Not much is heard or known about other Akan settlements like the Akwamu, the Akyem , the Akuapem, the Denkyira, the Abron, the Aowin, the Ahanta, the Anyi, the Baoule, the Chokosi, the Fante, the Kwahu, the Sefwi, the Ahafo, the Assin, the Evalue, the Wassa the Adjukru, the Akye, the Alladian, the Attie,the M'Bato, the Abidji, the Avikam,the Avatime the Ebrie,
Copied from the Book; " Reality as Myth " by Onyeji Nnaji The beauty of the discovering of the Radar Rivers and their channels is that it disproves the western hegemonic claim of the Euphrates valley being the position of the birth of the great river, all the points that opposed their claims notwithstanding. Even God himself was very perfect in His creation by placing them in their positions, hierarchically, according to their birth. The first river that flowed located the Havilah land where there are good quality gold, bdellium and fine onyx stones. Pison was the oldest of the rivers and it flowed through the land of the southern Africa. The second river flowed northward to Ethiopia. It was when Africa had been overtaken by virtue of her proximity to the Great Water that other parts of the world began to encounter the remaining river; remarkable with Hiddekel. Subscribe to ajuede.com to be updated on our posts on dailies. The major problem tow
Copied from the book, Reality as Myths by Onyeji Nnaji T he world of the Bantu travellers shows the walls of the migration that recorded the highest population among the African settlement. Originating from the largest population among the four races that settled in the east before time, all Bantu travellers were pygmies; for that was the nature of the Umudiala, the generation that gave birth to them. Bantu migration was rated the third earliest migration of the Negro race from the east. In this regard, all their movement had involved great population of people compared to the number of people involved in the two earlier populations that gave birth to Ethiopia, Nubia and Egypt: the Walker Traveller, and the Race of Anu. Bantu population as we have identified in the third chapter above outweighs the rest of the population of the ancient fathers that founded many of the nations of antiquity mentioned earlier. Discussing them in beat will pose a little challenge since
STRICTLY FOR COUPLES … You will know that the man is the head while you are his neck. As such, you direct his focus and make him fixative Our series include the following : * Show him what he looks out for from other women * Teach him like he knows nothing * Learn to play naked games with your husband * Learn to package yourself * Learn to work on your husband M y neighbour had v owed never to let any girl survive as a salesgirl in my shop. This thing has happened for over three times. Each time we brought a new salesgirl, the girl would stay for two or three months; and suddenly she would end her contract with us. In all these, my husband did not know. So, being that the girls usually stole money and other items, the reason for their departure became genuine, thus: they ran away to avoid being punished for their actions. But behind this, the underlying truth is that the girls had been embarrassed by my neighbour who would warn them to leave her loosed husband. Re
T he name Nkalaha is a coinage which stands for a people occupying a geographical land and regional setting in the eastern part of Nigeria. It is a coinage which attempts to explain the direction of movement and adventure of the men who founded the community in the 15th century AD. According to oral sources and some documentation about this community, some of these men were believed to have traveled from Ida, old Benue state of Nigeria to inhabit the land. These men had traveled on different days to locate the place. Onojah who originally founded the land was said to have been in a deep search for a place of safety as he was besieged by a fate that appeared to make him somewhat incompatible with his own people. Nkalaha is one of the communities that make up Ishielu Local Government Area of Ebonyi State. Nkalaha occupied the northern part of Ishielu Local Government Area. She is located through the zip 135.031.000. The community sits on 923.768km 2 . She shares boundaries
The Mystery of Number, “Five” in the Igbo Cosmology. From: Aspects of the Ancient African Metaphysics; Chapter: Seven; Topic: Igbo Geometries and the Metaphysics of Numbers. Author: Onyeji Nnaji. I n the Igbo cosmology, the word Isee is a definite symbolic word as revealed through the Igbo language and culture. A human being has five fingers, five toes. The hands and feet are fundamentals to the survival in life as they are necessary in ensuring that man moves to places where he gets food and grapples on the food to sustain his life. To this view, the rhetoric that binds vocatives in the form of incantation (anchoring on the heart-lock: four ) and the concomitant reprisal in the manner of affirmation that holds the human life bind to his original spiritual person, therefore defining existence and essences are unified by the corresponding echo: Isee!!!!! Therefore it stands that anytime a prayer is said in the Igbo land, the attendants who would want the fulfillment of the
INTRODUCTION One thing that made Udi remarkable is the indubitable legacy adopted in commemoration of the legendry fighter, Uto at Nsude. It was one of the greatest contributions of the descendants of Agbaja to the survival of Nsukka civilization of memory. Uto held from Oshie. Uto dies of small pox after a mercenary battle he was hired to fight in the ancient Benin. His body was buried in the evil forest as the tradition demanded. Although he lived no longer, the stepped pyramids above were adopted to commemorate the lasting peace he brought to the entire Oshie and Udi nation of people. Another remarkable thing about Udi is the fertility of the land. This has contributed widely in sustaining the inhabitants and provided a name for the inhabitants in the manner of Abakaliki, Umudike, Ogbaru, Igboariam, Ohaji, Uzouwani, etc., especially in Amofia-Agu, Affa. Udi is a land of great rivers and springs: Adaada, Ajali, Oji, Aria, Nvenu, Ngene Evu, Iyi Ububo, etc. as was the situ
There are four generations…, and the fourth generation, which is the most exalted, is kingless and perfect. These people will enter the holy place of their Father and they will reside in rest … They are kings. They are the immortal within the mortal ( The Nag Hammadi, 219 ) Also read Nsukka Civilization: The Peopling of Ancient Nsukka One of the African homes that colonialism has completely deformed beyond certain level of recognition is Nsukka. Colonialism apart, the most affecting factor to the survival of the meaning which the rich cultural enclave, Nsukka, carries will best be blamed on postcolonial political structure. The biggest harm all these have against Nsukka as a people is that they rubbed her of the meaning of her name; their place of origin; how their fathers managed to come into their present abodes and who their ancestors were. A profound understanding of the excerpt above will open the door towards deciphering the meaning and origin of the people call
by Onyeji Nnaji Eha-Amufu road newly constructed by Governor Ifeanyi Ugwuanyi of Enugu state in 2019 A part from the strategic location of the Federal College of Education, one central reason remarkable about Eha-Amufu is her central position and her boundary situation. Eha-Amufu stands at the centre of many communities; as a result she has served as the gateway to different communities. She is bounded to Nkalaha, Agala, Ikem, Umuero and other communities, including Obeagu (pronounced Ubegu). Aside from that, Eha-Amufu embodies the route that traces the way to the northern part of Nigeria for travellers travelling from Ebonyi axis. Eha-Amufu also forms the remarkable boundary community between Enugu State and Ebonyi State. This situation makes Eha-Amufu very strategic in the discussion of the road and rivers across Ebonyi and Enugu. In the era when transportation on rail was the order of the day, the most popular then ‘Express Train and la