Sales of first big COVID-19 drug, remdesivir, may disappoint - analysis
A LAB technician works on investigational coronavirus disease treatment drug Remdesivir at Eva Pharma Facility in Cairo, Egypt, in June
(photo credit: AMR ABDALLAH DALSH / REUTERS)
"A lot of people were worried about the supply and wanted to keep remdesivir for their worst-case patients."
Investors betting on big profits from COVID-19 treatments may get an unwelcome surprise when Gilead Sciences Inc reports quarterly results this month. Its remdesivir, the first important coronavirus treatment, has not been used as much as first expected and faces complex insurance reimbursement issues.
Its best hope may be that the United States and other Northern Hemisphere governments concerned about a winter spike in cases are beginning to stockpile the antiviral drug, which is also being tested in combination with experimental COVID-19 antibody therapies.
Remdesivir has become the standard of care for patients hospitalized with severe COVID-19. But many doctors remain wary of using it more widely, raising questions about lofty analyst sales forecasts for a drug that could eventually be eclipsed by newer treatments.The World Health Organization on Thursday said its international trial of COVID-19 therapies found that remdesivir did not have a substantial effect on patients’ length of hospital stay or chances of survival. The study has not been reviewed by outside experts.
Gilead, whose shares have fallen 22% since the US Food and Drug Administration authorized remdesivir for emergency use in May, said the WHO findings are "inconsistent with more robust evidence."The company struggled to meet early demand and gave away around 250,000 courses earlier in the pandemic, when remdesivir was the only treatment proven to shorten hospital stays for severely ill patients.Since then, low-cost steroids have demonstrated an ability to cut death risk in severely ill COVID-19 patients, and doctors question the medical value of using remdesivir for moderately-ill patients.Wall Street forecast $2.5 billion in worldwide sales of remdesivir this year, according to Refinitiv. However, the US Department of Health and Human Services (HHS), which oversaw the drug's second-quarter distribution, said hospitals only bought 32% of 500,000 available courses - worth about $500 million at $3,120 per course.The European Union in July purchased 30,000 courses worth another $74 million. The EU recently contracted for 500,000 remdesivir courses over the next six months, but the deal does not require purchases.Gilead sells and licenses remdesivir to most of the world but is expected to get the vast majority of revenue from the United States and Europe.Johanna Mercier, Gilead's chief commercial officer, acknowledged that "hospitalization rates were much lower than originally predicted.""A lot of people were worried about the supply and wanted to keep remdesivir for their worst-case patients," she said.She declined in an interview to discuss Gilead's sales expectations, but said some of the excess US supply was soaked up by HHS for stockpiling, and some was diverted to Europe.The drug accounts for a fraction of Gilead's product sales, which totaled $21.7 billion in 2019. But the company in July raised its 2020 outlook, implying remdesivir sales of up to $3 billion, according to analysts.REIMBURSEMENT POLICYPublic health authorities have said that COVID-19 patients are not being denied drugs because of cost, but US hospital incentives are complex.Most commercial insurers as well as Medicare, the federal health plan for seniors, pay hospitals a flat per-patient rate for care, based on diagnosis. That creates an incentive to "avoid keeping people in the hospital," and makes a drug that shortens stays cost-effective, said Richard Trembowicz, healthcare reimbursement specialist at ECG Management Consultants.Medicare in March approved a 20% increase in its payment for hospital stays related to COVID-19 but does not reimburse directly for remdesivir, which costs $3,120 for a five-day course, or $2,340 for government purchasers.US hospitals say the cost is not influencing clinical decisions."The price is not outrageous enough," said Katherine Perez, infectious disease pharmacist at Houston Methodist Hospital. "We are hoping it is getting patients out of the hospital sooner."But, she added, "I don't think the data supports using it in more mild infections."Still, the FDA in August expanded its remdesivir authorization to include patients with less-severe illness."I would use it in an elderly person or someone on a drug that suppresses the immune system," said Dr. Rajesh Gandhi, an infectious disease physician at Massachusetts General Hospital in Boston. "For a 30-year-old doing well it would be less likely."Gilead's Mercier said reserving remdesivir for patients who need oxygen "is not necessarily the best use" of the drug, since antivirals may work best early in an infection, before a virus has reproduced enough to cause damage.The drug, which failed as a treatment for Ebola, is designed to prevent viruses from replicating and overwhelming their host's immune system.Meanwhile, Gilead is moving ahead with remdesivir development, including testing an inhaled formulation to see if it could help non-hospitalized patients
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Like our page on facebook @ Info4everybody Last Wednesday, we published the success story from Dr. Vladimir Zelenko, a board-certified family practitioner in New York, after he successfully treated 350 coronavirus patients with 100 percent success using a cocktail of drugs: hydroxychloroquine, in combination with azithromycin (Z-Pak), an antibiotic to treat secondary infections, and zinc sulfate. Dr. Zelenko said he saw the symptom of shortness of breath resolved within four to six hours after treatment. Do you know that the ancient Egypt were civilized by architects from the (500,000 - 4000 BC) Nsukka Civiliation? Now, Dr. Zelenko provides updates on the treatment after he successfully treated 699 COVID-19 patients in New York. In an exclusive interview with former New York Mayor, Rudy Giuliani, Dr. Vladmir Zelenko shares the results of his latest study, which showed that out of his 699 patients treated, zero patients died, zero patients intubated, and four ho
THE AKAN Copied from the book, Reality as Myth by Onyeji Nnaji . The influence of the Akan on their content nations lies on their population and commonwealth of their brother nations. The Akan are one of the largest ethnic groups in West Africa. Their population is scattered across West Africa and beyond. Among this huge population of the Akan, the Ghanaians are more popular, perhaps because of the political influence of the Ashanti Empire in the area. Not much is heard or known about other Akan settlements like the Akwamu, the Akyem , the Akuapem, the Denkyira, the Abron, the Aowin, the Ahanta, the Anyi, the Baoule, the Chokosi, the Fante, the Kwahu, the Sefwi, the Ahafo, the Assin, the Evalue, the Wassa the Adjukru, the Akye, the Alladian, the Attie,the M'Bato, the Abidji, the Avikam,the Avatime the Ebrie,
Copied from the Book; " Reality as Myth " by Onyeji Nnaji The beauty of the discovering of the Radar Rivers and their channels is that it disproves the western hegemonic claim of the Euphrates valley being the position of the birth of the great river, all the points that opposed their claims notwithstanding. Even God himself was very perfect in His creation by placing them in their positions, hierarchically, according to their birth. The first river that flowed located the Havilah land where there are good quality gold, bdellium and fine onyx stones. Pison was the oldest of the rivers and it flowed through the land of the southern Africa. The second river flowed northward to Ethiopia. It was when Africa had been overtaken by virtue of her proximity to the Great Water that other parts of the world began to encounter the remaining river; remarkable with Hiddekel. Subscribe to ajuede.com to be updated on our posts on dailies. The major problem tow
Copied from the book, Reality as Myths by Onyeji Nnaji T he world of the Bantu travellers shows the walls of the migration that recorded the highest population among the African settlement. Originating from the largest population among the four races that settled in the east before time, all Bantu travellers were pygmies; for that was the nature of the Umudiala, the generation that gave birth to them. Bantu migration was rated the third earliest migration of the Negro race from the east. In this regard, all their movement had involved great population of people compared to the number of people involved in the two earlier populations that gave birth to Ethiopia, Nubia and Egypt: the Walker Traveller, and the Race of Anu. Bantu population as we have identified in the third chapter above outweighs the rest of the population of the ancient fathers that founded many of the nations of antiquity mentioned earlier. Discussing them in beat will pose a little challenge since
STRICTLY FOR COUPLES … You will know that the man is the head while you are his neck. As such, you direct his focus and make him fixative Our series include the following : * Show him what he looks out for from other women * Teach him like he knows nothing * Learn to play naked games with your husband * Learn to package yourself * Learn to work on your husband M y neighbour had v owed never to let any girl survive as a salesgirl in my shop. This thing has happened for over three times. Each time we brought a new salesgirl, the girl would stay for two or three months; and suddenly she would end her contract with us. In all these, my husband did not know. So, being that the girls usually stole money and other items, the reason for their departure became genuine, thus: they ran away to avoid being punished for their actions. But behind this, the underlying truth is that the girls had been embarrassed by my neighbour who would warn them to leave her loosed husband. Re
T he name Nkalaha is a coinage which stands for a people occupying a geographical land and regional setting in the eastern part of Nigeria. It is a coinage which attempts to explain the direction of movement and adventure of the men who founded the community in the 15th century AD. According to oral sources and some documentation about this community, some of these men were believed to have traveled from Ida, old Benue state of Nigeria to inhabit the land. These men had traveled on different days to locate the place. Onojah who originally founded the land was said to have been in a deep search for a place of safety as he was besieged by a fate that appeared to make him somewhat incompatible with his own people. Nkalaha is one of the communities that make up Ishielu Local Government Area of Ebonyi State. Nkalaha occupied the northern part of Ishielu Local Government Area. She is located through the zip 135.031.000. The community sits on 923.768km 2 . She shares boundaries
The Mystery of Number, “Five” in the Igbo Cosmology. From: Aspects of the Ancient African Metaphysics; Chapter: Seven; Topic: Igbo Geometries and the Metaphysics of Numbers. Author: Onyeji Nnaji. I n the Igbo cosmology, the word Isee is a definite symbolic word as revealed through the Igbo language and culture. A human being has five fingers, five toes. The hands and feet are fundamentals to the survival in life as they are necessary in ensuring that man moves to places where he gets food and grapples on the food to sustain his life. To this view, the rhetoric that binds vocatives in the form of incantation (anchoring on the heart-lock: four ) and the concomitant reprisal in the manner of affirmation that holds the human life bind to his original spiritual person, therefore defining existence and essences are unified by the corresponding echo: Isee!!!!! Therefore it stands that anytime a prayer is said in the Igbo land, the attendants who would want the fulfillment of the
INTRODUCTION One thing that made Udi remarkable is the indubitable legacy adopted in commemoration of the legendry fighter, Uto at Nsude. It was one of the greatest contributions of the descendants of Agbaja to the survival of Nsukka civilization of memory. Uto held from Oshie. Uto dies of small pox after a mercenary battle he was hired to fight in the ancient Benin. His body was buried in the evil forest as the tradition demanded. Although he lived no longer, the stepped pyramids above were adopted to commemorate the lasting peace he brought to the entire Oshie and Udi nation of people. Another remarkable thing about Udi is the fertility of the land. This has contributed widely in sustaining the inhabitants and provided a name for the inhabitants in the manner of Abakaliki, Umudike, Ogbaru, Igboariam, Ohaji, Uzouwani, etc., especially in Amofia-Agu, Affa. Udi is a land of great rivers and springs: Adaada, Ajali, Oji, Aria, Nvenu, Ngene Evu, Iyi Ububo, etc. as was the situ
There are four generations…, and the fourth generation, which is the most exalted, is kingless and perfect. These people will enter the holy place of their Father and they will reside in rest … They are kings. They are the immortal within the mortal ( The Nag Hammadi, 219 ) Also read Nsukka Civilization: The Peopling of Ancient Nsukka One of the African homes that colonialism has completely deformed beyond certain level of recognition is Nsukka. Colonialism apart, the most affecting factor to the survival of the meaning which the rich cultural enclave, Nsukka, carries will best be blamed on postcolonial political structure. The biggest harm all these have against Nsukka as a people is that they rubbed her of the meaning of her name; their place of origin; how their fathers managed to come into their present abodes and who their ancestors were. A profound understanding of the excerpt above will open the door towards deciphering the meaning and origin of the people call
by Onyeji Nnaji Eha-Amufu road newly constructed by Governor Ifeanyi Ugwuanyi of Enugu state in 2019 A part from the strategic location of the Federal College of Education, one central reason remarkable about Eha-Amufu is her central position and her boundary situation. Eha-Amufu stands at the centre of many communities; as a result she has served as the gateway to different communities. She is bounded to Nkalaha, Agala, Ikem, Umuero and other communities, including Obeagu (pronounced Ubegu). Aside from that, Eha-Amufu embodies the route that traces the way to the northern part of Nigeria for travellers travelling from Ebonyi axis. Eha-Amufu also forms the remarkable boundary community between Enugu State and Ebonyi State. This situation makes Eha-Amufu very strategic in the discussion of the road and rivers across Ebonyi and Enugu. In the era when transportation on rail was the order of the day, the most popular then ‘Express Train and la